منابع مشابه
p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.
The p53 transcription factor is either latent or activated through multi-site phosphorylation and acetylation of the negative regulatory region in its C-terminal domain (CTD). How CTD modifications activate p53 binding to target DNA sequences via its core domain is still unknown. It has been proposed that nonmodified CTD interacts either with the core domain or with DNA preventing binding of th...
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Kaposi sarcoma-associated herpesvirus (KSHV) is linked with all clinical forms of Kaposi sarcoma and several lymphoproliferative disorders. Like other herpesviruses, KSHV becomes latent in the infected cells, expressing only a few genes that are essential for the establishment and maintenance of its latency and for the survival of the infected cells. Inhibiting the expression of these latent ge...
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A prominent challenge in the support of Wide Area Applications (WAA) involves their unpredictable behavior over a dynamic WAN that results in a considerable variability in access latency (end-toend delay). Latency profiles capture the changing latencies that clients experience when accessing a server and can be utilized as a WAA monitoring and optimization tool. However, in the presence of hund...
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Both hardware and software prefetching have been shown to be eeective in tolerating the large memory latencies inherent in shared-memory multiprocessors; however, both types of prefetching have their shortcomings. In this paper, we propose an integrated hardware/software prefetching method that uses simple hardware that can handle most data accesses and software prefetching for the few remainin...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m100482200